Description
Indications
Propafenone 150 mg Tablets are used for:
- Prevention of paroxysmal atrial fibrillation (PAF) and atrial flutter
- Management of paroxysmal supraventricular tachycardia (PSVT)
- Treatment of life-threatening ventricular arrhythmias such as sustained ventricular tachycardia
- Stabilization of irregular or rapid heartbeats to reduce symptoms like palpitations, chest discomfort, and dizziness
Mechanism of Action
Propafenone acts as a sodium channel blocker, slowing conduction in cardiac tissues and increasing the refractory period. This stabilizes abnormal heart rhythms and reduces the likelihood of dangerous arrhythmias. It also possesses mild beta-blocking effects, further supporting cardiac rhythm control.
Dosage & Administration
- Initial dose: 150 mg orally every 8 hours (450 mg/day).
- Adjustment: Can be increased gradually up to 225–300 mg every 8 hours (maximum 900 mg/day) as per physician’s guidance.
- Administration: Should be taken with food to improve absorption.
- Monitoring: Initiation is usually carried out in a hospital setting under ECG monitoring to detect any conduction abnormalities or arrhythmia aggravation.
Precautions & Warnings
- Should only be used for serious arrhythmias due to potential risk of proarrhythmia.
- Contraindicated in patients with structural heart disease, heart failure, AV block (without pacemaker), severe hypotension, or Brugada syndrome.
- Dose adjustment required in liver impairment.
- May interact with other antiarrhythmic drugs, beta-blockers, and CYP2D6/3A4 inhibitors.
- Regular ECG monitoring is advised.
Possible Side Effects
- Dizziness, fatigue, metallic taste, nausea, or gastrointestinal upset
- Bradycardia or hypotension
- Worsening of arrhythmias (rare but serious)
- Visual disturbances or blurred vision in some patients
Storage
Store in a cool, dry place at 20°C to 25°C, away from light and moisture. Keep out of reach of children.
Export & Contract Manufacturing
Aetos Life Care exports Propafenone Hydrochloride Tablets USP 150 mg to both regulated and semi-regulated markets with complete support for regulatory documentation, logistics, and quality certifications. Our manufacturing facilities are WHO-GMP certified and fully compliant with stringent international pharmaceutical standards, ensuring consistent quality and safety in every batch.
Available for International Distribution
Propafenone Hydrochloride 150 mg Tablets are available for distribution in Latin America, Africa, Asia, Europe, and the Middle East. We provide customized support based on local regulatory requirements, including dossier preparation, bioequivalence data, and country-specific product registrations, enabling our partners to expand their cardiology product portfolio seamlessly.
Third-Party & Private Label Options
Aetos Life Care offers flexible third-party manufacturing and private label solutions for Propafenone Hydrochloride 150 mg Tablets. Distributors, importers, and marketing companies can launch the product under their own brand with full customization in formulation, packaging, and multilingual branding. Our services ensure cost-effective market entry with minimal investment and maximum compliance.
