Description
Mechanism of Action:
Nicorandil has a dual action:
✔ Potassium Channel Activation → Relaxes vascular smooth muscles, causing vasodilation and improved blood supply to the heart.
✔ Nitrate-Like Action → Dilates coronary arteries and reduces myocardial oxygen demand, preventing chest pain.
Indications:
✔ Chronic Stable Angina – Prevents and controls angina symptoms.
✔ Coronary Artery Disease (CAD) Management – Helps improve cardiac blood flow.
✔ Hypertension (Off-label use) – Used in some cases for blood pressure control.
Key Benefits:
✅ Reduces angina frequency and severity.
✅ Improves blood flow to the heart.
✅ Dual mechanism for better cardiovascular protection.
✅ Long-acting medication for sustained relief.
Dosage & Administration:
- Nicorandil 10 mg – Taken twice daily or as prescribed.
- Route of Administration: Oral.
- Food Intake: Can be taken with or without food.
Precautions & Warnings:
- Avoid abrupt discontinuation to prevent rebound angina.
- May cause dizziness or headache; caution while driving.
- Not suitable for patients with severe hypotension or recent myocardial infarction.
- Avoid use with phosphodiesterase inhibitors (e.g., Sildenafil/Viagra) due to the risk of severe hypotension.
Possible Side Effects:
- Headache (common and temporary).
- Dizziness or low blood pressure.
- Flushing or palpitations.
- Ulcers (rare but possible with prolonged use).
Storage & Packaging:
- Store at below 30°C in a dry place.
- Available in blister packs and bottles for export.
- Custom packaging available for bulk supply.
Manufacturing & Regulatory Compliance:
Manufactured by Aetos Life Care in WHO-GMP accredited facilities, following EU-GMP standards for quality assurance and global compliance.
Global Export & Supply:
Aetos Life Care exports Nicorandil Tablets 10 mg to Latin America, Africa, Asia, Europe, and CIS countries, ensuring high-quality pharmaceutical solutions for cardiovascular care.
