Description
Mechanism of Action:
✔ Binds to α2δ-1 subunit of voltage-gated calcium channels – reduces the release of excitatory neurotransmitters involved in pain signaling.
✔ Longer receptor binding duration – leads to prolonged analgesic effects with lower doses.
✔ Effective in chronic neuropathic pain disorders, including diabetic neuropathy and postherpetic neuralgia.
Indications:
✔ Diabetic Peripheral Neuropathy (DPN)
✔ Postherpetic Neuralgia (PHN)
✔ Chronic Neuropathic Pain Syndromes
Key Benefits:
✅ More potent and longer-lasting pain relief compared to pregabalin.
✅ Lower incidence of dizziness and sedation than older gabapentinoids.
✅ Well-tolerated in elderly patients with neuropathic pain.
✅ Less frequent dosing due to prolonged receptor binding.
✅ Improves sleep disturbances associated with chronic pain.
Dosage & Administration:
- Recommended Dosage: Initial dose of 5 mg twice daily, titrated up to 15 mg twice daily based on patient response.
- Route of Administration: Oral.
- Food Intake: Can be taken with or without food.
- Dose adjustments required in patients with renal impairment.
Precautions & Warnings:
- May cause drowsiness—caution while driving or operating heavy machinery.
- Use with caution in patients with a history of substance abuse.
- Dose adjustments needed for patients with severe kidney disease.
- Avoid abrupt discontinuation to prevent withdrawal symptoms.
- Not recommended for use in pregnancy unless absolutely necessary.
Possible Side Effects:
- Dizziness or somnolence
- Mild weight gain
- Peripheral edema (swelling of legs or feet)
- Mild cognitive impairment (rare at low doses)
- Gastrointestinal discomfort (nausea or constipation)
Storage & Packaging:
- Store at below 30°C in a dry, dark place, away from moisture.
- Available in blister packs and bulk packaging, customizable for client needs.
Manufacturing & Regulatory Compliance:
Manufactured by Aetos Life Care in WHO-GMP certified facilities, following EU-GMP guidelines to ensure global pharmaceutical standards.
Global Export & Supply:
Aetos Life Care exports Mirogabalin Besylate Tablets 10 mg, 15 mg to Latin America, Africa, Asia, Europe, and CIS countries, offering innovative and cost-effective neuropathic pain management solutions worldwide.
