Description
Mechanism of Action:
✔ Releases nitric oxide (NO) → Activates guanylate cyclase, leading to vascular smooth muscle relaxation.
✔ Dilates coronary arteries → Increases blood flow to the heart, relieving angina.
✔ Reduces myocardial oxygen demand → Helps prevent heart attacks in high-risk patients.
Indications:
✔ Acute Angina Relief – Provides rapid relief from chest pain.
✔ Angina Prevention – Used before exertion to prevent angina attacks.
✔ Heart Failure (Adjunct Therapy) – Helps reduce cardiac workload.
Key Benefits:
✅ Fast-acting relief from angina pain.
✅ Prevents chest pain episodes in high-risk patients.
✅ Improves heart efficiency and reduces oxygen demand.
✅ Sublingual formulation ensures rapid absorption.
Dosage & Administration:
- Nitroglycerin 0.5 mg – Place one tablet under the tongue at the first sign of chest pain; may repeat every 5 minutes if needed (max 3 tablets in 15 minutes).
- Route of Administration: Sublingual (under the tongue).
- Food Intake: Can be taken with or without food; do not swallow or chew.
Precautions & Warnings:
- Do not take with phosphodiesterase inhibitors (e.g., Sildenafil, Tadalafil) due to risk of severe hypotension.
- May cause dizziness or fainting; avoid sudden standing after taking.
- Seek medical attention if chest pain persists after 3 doses.
- Store in a tightly sealed container to prevent loss of potency.
Possible Side Effects:
- Headache (common and usually temporary).
- Dizziness or low blood pressure.
- Flushing or palpitations.
- Nausea.
Storage & Packaging:
- Store at below 25°C in a dry, cool place, away from moisture.
- Available in sealed blister packs for freshness and potency.
- Custom packaging options for bulk supply.
Manufacturing & Regulatory Compliance:
Manufactured by Aetos Life Care in WHO-GMP accredited facilities, following EU-GMP standards for global regulatory compliance.
Global Export & Supply:
Aetos Life Care exports Nitroglycerin Tablets 0.5 mg to Latin America, Africa, Asia, Europe, and CIS countries, ensuring high-quality pharmaceutical solutions for cardiovascular care.
